Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy

摘要: The exchange proteins directly activated by cAMP 1 and 2 (Epac1 Epac2) are expressed in a cell specific manner the liver, but their biological functions this tissue poorly understood. current study was undertaken to begin determine potential roles of Epac1 Epac2 liver physiology disease. Male C57BL/6J mice which expression and/or deleted, were subjected partial hepatectomy regenerating analyzed with regard lipid accumulation, replication protein expression. In response hepatectomy, deletion led increased hepatocyte proliferation 36 h post surgery, transient steatosis observed wild type virtually absent lacking both Epac2. cytochrome P4504a14, is implicated hepatic fibrosis, substantially reduced upon Epac1/2, while number factors involved metabolism significantly decreased. Moreover, Kupffer cells affected, further supporting role for these function. This establishes phenotypic abnormalities deleted Epac1/2 first time, introduces as regulators accumulation regenerative process.