gamma Interferon production appears to predict time of recurrence of herpes labialis.

摘要: Peripheral blood mononuclear cells separated from the of 29 volunteers within 3 wk onset recurrent oral herpes labialis spontaneously secreted IFN-gamma (and small amounts IFN-beta) into culture medium in varying (mean = 77 U/ml, SE 17). However, interferon could not be detected serum 10 these patients tested. In group as a whole, peak levels were vitro at 6 to 20 days after labialis. Serial studies eight showed production second or third week, with subsequent decrease undetectable wk. A strong correlation between supernatant level and time next recurrence each patient was noted (r 0.82, p less than 0.0001). Herpes simplex antigen-stimulated cell cultures produced mixture IFN-alpha IFN-gamma. marked but still significant mixed inter-recurrence interval 0.52, 0.005). These results suggest that acts an vivo stimulus induction IFN-gamma-producing circulate peripheral blood. The is either direct determinant frequency quantitative marker for other cellular immune events determining frequency.