Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene.

摘要: Abstract In this study, we report the development and evaluation of soy lecithin-chitosan hybrid nanoparticles to improve oral bioavailability raloxifene hydrochloride. The were formed by interaction negatively charged lecithin with positively chitosan. ratio chitosan was critical for charge, hence size nanoparticles. optimal 20:1 obtain particle 208 ± 3 nm, a ζ-potential 36 ± 2 mV an entrapment efficiency 73 ± 3%. also characterized differential scanning calorimetry FT-IR spectrophotometer. In-vitro drug release assessed using dialysis bag method in pH 7.4 buffer. loaded did not cause significant reduction cell viability at low doses. Pharmacokinetic studies female Wistar rats showed improvement (~4.2 folds) when into Further, modified everted gut sac study that these are taken up active endocytic processes intestine. ex-vivo mucoadhesion proved get bound mucus layer intestine, which turn correlates reduced excretion faeces. conclusion, proposed appear promising effective delivery poorly bioavailable drugs like