Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease.
作者： Jams Metuzals , Yves Robitaille , Susan Houghton , Serge Gauthier , Richard Leblanc
DOI: 10.1007/BF01216709
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摘要: The cytoplasmic-nuclear interface has been investigated by conventional thin sectioning electron microscopy of neurons from frontal lobe biopsies 13 patients with Alzheimer's disease. Nine were in the early and intermediate stages disease four advanced stage. Fascicles paired helical filament-like strands filaments appose nuclear envelope, pore complexes perinuclear polysomes. Paired filament profiles have also identified nucleoplasm. These observations indicate that and, consequently, relationships between cytoplasm nucleus, might be impaired
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S. Gauthier, R. Leblanc, R. Quirion, G. Carlsson, M. Beaulieu, R. Bouchard, D. Dastoor, F. Ervin, L. Gauthier, M. Gauvin, J. Henry, R. Palmour, Y. Robitaille, Transmitter-replacement therapy in Alzheimer's disease using intracerebroventricular infusions of receptor agonists. Canadian Journal of Neurological Sciences. ,vol. 13, pp. 394- 402 ,(1986) , 10.1017/S0317167100036969
J. Metuzals, Y. Robitaille, S. Houghton, S. Gauthier, R. Leblanc, Transformation of the Neurofilamentous Network Components into PHF-Like Strands and PHF Paracrystals Advances in Behavioral Biology. ,vol. 34, pp. 75- 95 ,(1987) , 10.1007/978-1-4613-1657-2_7
Sanford L Palay, Alan Peters, Henry de F Webster, The fine structure of the nervous system: The neurons and supporting cells ,(1976)
Murray L. Barr, The Significance of the Sex Chromatin International Review of Cytology-a Survey of Cell Biology. ,vol. 19, pp. 35- 95 ,(1966) , 10.1016/S0074-7696(08)60564-1
J. Metuzals, H. Pant, H. Gainer, P.A.M. Eagles, N.S. White, S. Houghton, In vitro polymorphism and phase transitions of the neurofilamentous network isolated from the giant axon of the squid (Loligo pealei L.). Cell and Tissue Research. ,vol. 252, pp. 249- 262 ,(1988) , 10.1007/BF00214367
Matti Haltia, Hannu Somer, Jorma Palo, William G. Johnson, Neuronal intranuclear inclusion disease in identical twins Annals of Neurology. ,vol. 15, pp. 316- 321 ,(1984) , 10.1002/ANA.410150403
Y. Robitaille, J. Metuzals, S. Houghton, R. Leblanc, S. Gauthier, DISINTEGRATION OF THE BLOOD BRAIN BARRIER AND PELIOSIS IN ALZHEIMERʼS DISEASE: 195 Journal of Neuropathology and Experimental Neurology. ,vol. 46, pp. 397- ,(1987) , 10.1097/00005072-198705000-00202
Ueli Aebi, Julie Cohn, Loren Buhle, Larry Gerace, The nuclear lamina is a meshwork of intermediate-type filaments. Nature. ,vol. 323, pp. 560- 564 ,(1986) , 10.1038/323560A0
Robert D. Goldman, The role of three cytoplasmic fibers in BHK-21 cell motility. I. Microtubules and the effects of colchicine. Journal of Cell Biology. ,vol. 51, pp. 752- 762 ,(1971) , 10.1083/JCB.51.3.752
ROBERT GOLDMAN, ANNE GOLDMAN, KATHLEEN GREEN, JONATHAN JONES, NORMAN LIESKA, HSI-YUAN YANG, Intermediate filaments: possible functions as cytoskeletal connecting links between the nucleus and the cell surface. Annals of the New York Academy of Sciences. ,vol. 455, pp. 1- 17 ,(1985) , 10.1111/J.1749-6632.1985.TB50400.X