Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate.

摘要: PURPOSE This study aimed to investigate potential biomarkers for the diagnosis of overactive bladder (OAB). METHODS A total 219 subjects were enrolled and divided into 2 groups: OAB (n=189) controls without symptoms (n=30). Three-day voiding diaries questionnaires collected, urinary levels nerve growth factor (NGF), prostaglandin E2, adenosine triphosphate measured normalized urine creatinine (Cr). Baseline characteristics markers analyzed. receiver-operator characteristic (ROC) curve was used analyze diagnostic performance markers. Urinary according subgroup pathogenesis evaluated. Correlation analyses relationship between diary parameters questionnaires. RESULTS There no difference groups with regards age, sex ratio, or Cr (P>0.05). The NGF/Cr higher in than (P<0.001). a sensitive biomarker discriminating patients (area under curve=0.741; 95% confidence interval, 0.62-0.79; P=0.001) ROC curve. significantly regardless pathogenesis. analysis demonstrated urgency related level (correlation coefficient, 0.156). Limitations include relatively wide variation CONCLUSIONS NGF is that could serve as basis adjunct OAB.