Reliability and validity of urinary nerve growth factor measurement in women with lower urinary tract symptoms.

摘要: Introduction and Hypothesis The validity reliability of measurement urinary NGF as a diagnostic biomarker in women with lower tract dysfunction (LUTD) is uncertain. We aimed to evaluate both the discriminant validity, test–retest LUTD. Methods Urinary was measured LUTD (n = 205) asymptomatic subjects (n = 31). Urinary assayed using an ELISA method normalized against creatinine. NGF/creatinine ratios were compared between symptom subgroups Mann–Whitney U test, different urodynamic diagnoses Kruskal–Wallis test. Receiver Operator Characteristic (ROC) analysis employed performance NGF. Test–retest assessed intra-class correlation (ICC). Results Urinary significantly but non-specifically increased symptomatic patients when controls (13.33 vs. 2.05 ng NGF/g Cr, P < 0.001). On multivariate logistic regression good predictor having OAB or not, however, adjusted odds ratio only 1.006. ROC demonstrated poor ability groups groups. Using cut off 13.0 ng creatinine test provides sensitivity 81%, specificity 39% for overactive bladder. The assays test-retest ICC 0.889. Conclusions Although can be reliably assayed, various LUTDs, it discriminates poorly these disorders therefore has very limited potential biomarker. Neurourol. Urodynam. 35:944–948, 2016. © 2015 Wiley Periodicals, Inc.