Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma
作者： Ting-Ying Fu , Chao-Nan Wu , Huei-Cin Sie , Jiin-Tsuey Cheng , Yaoh-Shiang Lin
DOI: 10.18632/ONCOTARGET.13197
关键词:
摘要: // Ting-Ying Fu 1, 2, * , Chao-Nan Wu 3, 4, Huei-Cin Sie 1 Jiin-Tsuey Cheng 5 Yaoh-Shiang Lin 6 Huei-Han Liou 7 Yu-Kai Tseng 8, 9 Chih-Wen Shu Kuo-Wang Tsai 7, 10 Leing-Ming Yen Hui-Wen 11, 12 Ching-Jiunn 13, 14, 15 Luo-Ping Ger 16 Pei-Feng Liu 17 Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2 Optometry, Shu-Zen Junior College Medicine Management, 3 Stomatology, 4 Dental Technology, Biological Sciences, National Sun Yat-Sen University, Otorhinolaryngology-Head & Neck Surgery, Medical Education Research, 8 Orthopedics, Show Chwan Memorial Changhua, Kung University Tainan, Chemical Biology, Pingtung Education, Pingtung, 11 Dermatology, Nursing, Meiho 13 Institute Clinical Yang-Ming Taipei, 14 Pharmacology, Defense Center, China Taichung, Biomedical Biotechnology, Fooyin These authors have contributed equally to this work Correspondence to: Ger, email: lpger@vghks.gov.tw Liu, pfliu@vghks.gov.tw Keywords: DDX60, oral cancer, subsite-specific, tumorigenesis, prognosis Received: April 2016 Accepted: October 28, Published: November 08, 2016 ABSTRACT The clinical significance biological function DEXD/H box helicase 60 (DDX60) in cancer remains unknown. Herein, we evaluated the association DDX60 expression with tumorigenesis squamous cell carcinoma (OSCC). was examined by immunohistochemistry on tissue microarray slides 494 OSCC patients, including 180 buccal mucosal SCC (BMSCC), 241 tongue (TSCC), 73 lip (LSCC) patients. significantly increased all three subsites compared its tumor adjacent normal tissues. However, specific cavity subsite after stratification betel quid chewing, smoking, drinking. Among higher levels were associated male gender, a well-differentiated tumor, advanced stage disease, large size features. LSCC patients high showed shorter disease-specific survival, particularly those moderately or poorly differentiated tumors. Additionally, TSCC poor disease-free survival (DFS), Therefore, is novel unfavorable biomarker for subsite-specific manner.
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