IgE-mediated histamine release in rat basophilic leukemia cells: Receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid
作者： Fulton T. Crews , Yutaka Morita , Anne Mc Givney , Fusao Hirata , Reuben P. Siraganian
DOI: 10.1016/0003-9861(81)90399-4
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摘要: Abstract Stimulation of IgE receptors on rat basophilic leukemia cells causes a transient rise and fall methylated phopholipids, Ca 2+ influx, release arachidonic acid previously incorporated into phosphatidylcholine liberation histamine. Inhibition phospholipid methylation by methyltransferase inhibitors, 3-deazaadenosine homocysteine thiolactone, almost completely blocks the influx , immunoglobulin E antigen releases only [ 14 C]arachidonic but not C]linoleic acid, C]oleic C]stearic all which were phospholipids. C]Arachidonate was found to be mainly phosphatidylcholine. The phosphatidycholine rich in arachidonate appeared synthesized considerable extent transmethylation pathway. These findings suggest that cells, receptors, methyltransferases, ion channel, phospholipase(s) cause discharge histamine are associated.
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sci-hub.se 参考文章(22)
R. Kannagi, K. Koizumi, T. Masuda, Limited hydrolysis of platelet membrane phospholipids. On the proposed phospholipase-susceptible domain in platelet membranes. Journal of Biological Chemistry. ,vol. 256, pp. 1177- 1184 ,(1981) , 10.1016/S0021-9258(19)69946-1
S.L. Hong, D. Deykin, Specificity of phospholipases in methylcholanthrene-transformed mouse fibroblasts activated by bradykinin, thrombin, serum, and ionophore A23187. Journal of Biological Chemistry. ,vol. 254, pp. 11463- 11466 ,(1979) , 10.1016/S0021-9258(19)86508-0
Reuben P. Siraganian, Henry Metzger, Evidence that the “Mouse Mastocytoma” Cell Line (MCT-1) Is of Rat Origin Journal of Immunology. ,vol. 121, pp. 2584- 2585 ,(1978)
Gösta A.E. Arvidson, Reversed-phase partition thin-layer chromatography of rat liver lecithins to yield eight simple phosphatidyl cholines. Journal of Lipid Research. ,vol. 8, pp. 155- 158 ,(1967) , 10.1016/S0022-2275(20)38932-X
Anne Mc Givney, Yutaka Morita, Fulton T. Crews, Fusao Hirata, Julius Axelrod, Reuben P. Siraganian, Phospholipase activation in the IgE-mediated and Ca2+ ionophore A23187-induced release of histamine from rat basophilic leukemia cells Archives of Biochemistry and Biophysics. ,vol. 212, pp. 572- 580 ,(1981) , 10.1016/0003-9861(81)90400-8
G.J. BLACKWELL, W.G. DUNCOMBE, R.J. FLOWER, M.F. PARSONS, J.R. VANE, The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. British Journal of Pharmacology. ,vol. 59, pp. 353- 366 ,(1977) , 10.1111/J.1476-5381.1977.TB07500.X
Moseley Waite, Lawrence R. DeChatelet, Lynn King, Pamela S. Shirley, Phagocytosis-induced release of arachidonic acid from human neutrophils. Biochemical and Biophysical Research Communications. ,vol. 90, pp. 984- 992 ,(1979) , 10.1016/0006-291X(79)91924-7
M.A. Trewhella, F.D. Collins, Pathways of phosphatidylcholine biosynthesis in rat liver Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 296, pp. 51- 61 ,(1973) , 10.1016/0005-2760(73)90042-8
S. L. Katyal, B. Lombard, Quantitation of phosphatidyl N-methyl-and N,N-dimethylaminoethanol in rat liver. Lipids. ,vol. 11, pp. 513- 516 ,(1976) , 10.1007/BF02532895
Fulton T. Crews, Fusao Hirata, Julius Axelrod, Identification and Properties of Methyltransferases That Synthesize Phosphatidylcholine in Rat Brain Synaptosomes Journal of Neurochemistry. ,vol. 34, pp. 1491- 1498 ,(1980) , 10.1111/J.1471-4159.1980.TB11229.X