A magnetic nanogel based on O-carboxymethylchitosan for antitumor drug delivery: synthesis, characterization and in vitro drug release.
作者： Carla Albetina Demarchi , Aline Debrassi , Fátima de Campos Buzzi , Rogério Corrêa , Valdir Cechinel Filho
DOI: 10.1039/C3SM53157K
关键词:
摘要: This paper studied the synthesis, characterization and use of magnetic chitosan nanogel for carrying meleimidic compounds. The hydrogel polymer was prepared using O-carboxymethylchitosan, which crosslinked with epichlorohydrin subsequent incorporation iron oxide nanoparticles. revealed that material comprises about 10% hydrogel. is comprised magnetite maghemite exhibits ferro–ferrimagnetic behavior. average particle size 4.2 nm. There high efficiency maleimides in nanogel. release sustained character there a greater when an external field applied. mathematical model best explained process drug by Peppas–Sahlin. proved to be excellent candidate drug-delivery systems.
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