β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development

摘要: β-defensin family plays a role in host defense against viral infection, however its HCV infection is still unknown. In this study, we demonstrated that 1 was significantly reduced HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other tested, the extent duration of upregulation associated treatment response. We investigated expression cancer publicly available datasets found among all β-defensins only downregulated, suggesting crucial development. Further analysis identified E-cadherin as top positive correlated gene, while hepatocyte growth factor-regulated tyrosine kinase substrate negative gene. Expression two proteoglycans were also positively 1. have small molecules potential therapeutic agents to reverse 1-associated gene signature. Furthermore, downregulation E-cadherin, substrate, further confirmed adjacent normal tissue collected from in-house Chinese patients. Together, our results suggest an important protecting progression