The fasting hyperglycaemia study: I. Subject identification and recruitment for a non—insulin-dependent diabetes prevention trial
作者： M.S. Hammersley , L.C. Meyer , R.J. Morris , S.E. Manley , R.C. Turner
DOI: 10.1016/S0026-0495(97)90317-6
关键词:
摘要: Subjects at increased risk for developing non-insulin-dependent diabetes mellitus (NIDDM) were encouraged via a public awareness campaign, general practitioners, or direct approach (in the case of women with previous gestational diabetes) to attend one three English and two French centers fasting plasma glucose (FPG) measurement. Of 1,580 subjects (mean +/- SD age, 47 10 years), 29% male, 56% had diabetic relative, 20% history elevated blood glycosuria, 9% previously diabetes. Thirty-one percent (493) an initial ([IFG] 5.5 7.7 mmol.L-1), 3% (41) ([DFG] > = 7.8 66% (1,046) normal ([NFG] 6.2%), 75% fructosamine (> 282 mumol.L-1). While these glycemic measures provided good discrimination diabetes, neither reliable in detecting those but not FPG values. In conclusion, 293 (19%) self-referred identified as having persistently FPG, 227 have been entered into randomized NIDDM prevention trial evaluating healthy-living advice sulfonylurea therapy.
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