Positive Fluid Balance and Association with Post-Traumatic Acute Kidney Injury

摘要: Background Acute kidney injury (AKI) is common in severely injured trauma patients and associated with poor outcomes. A positive fluid balance AKI long-term renal outcomes among general ICU cardiac surgery patients. Currently, the optimal endpoint of resuscitation unknown, which may result excess administration. We hypothesized that after severe increased development. Study Design cohort study adult (≥16 years old) requiring admission from January 2017 to June was conducted. Patients were excluded for early death, rhabdomyolysis, or previous history end-stage disease congestive heart failure. within 7 days defined according Kidney Disease Improving Global Outcomes creatinine-based criteria. Univariate multivariable analyses performed. Results Of 364 patients, 74% male. The median age 41 (interquartile range [IQR] 27 59 years), Injury Severity Score (ISS) 18 (IQR 10 29). Positive (>2 L) observed 49% diagnosed 105 (29%) After adjustment, there an risk a >2 L (relative [RR] 1.98 [95% CI 1.24 3.17]). Additionally, incrementally by 1.22 each liter above zero (95% 1.11 1.34). Conclusions 2 at 48 hours occurs half positivity independently Fluid responsiveness should be investigated as end point post-traumatic prevent unnecessary administration subsequent AKI.