The Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test.
作者： Manzumeh-Shamsi Meymandi , Fariborz Keyhanfar , Omid Yazdanpanah , Gioia Heravi
DOI: 10.5812/AAPM.28968
关键词:
摘要: Background Pregabalin as a new anticonvulsant has been used in different pain treatments. Objectives The aim of this study was to investigate the role N-methyl-D-aspartate (NMDA) ligands antinociceptive effect pregabalin mice using tail flick. Materials and methods NMDA (15 30 mg/kg) an agonist or MK801 (0.02 0.05 antagonist were injected intraperitoneally either alone 15 minutes before dose (100 mg/kg). Then latency times %MPE measured flick assay during 75 minutes. Results had no effects alone. pretreatment significantly decreased till 75(th) In pretreated groups, %MPE30 unlike %MPE75 compared those pregabalin. delayed but did not change Conclusions Our findings support NMDARs antinociception, because NMDAR agonist, antagonist, pregabalin, even if is adequate assessment method regard.
kowsarpub.com
core.ac.uk参考文章(53)
Yasser Mohamed Amr, Multi-day low dose ketamine infusion as adjuvant to oral gabapentin in spinal cord injury related chronic pain: a prospective, randomized, double blind trial. Pain Physician. ,vol. 13, pp. 245- 249 ,(2010) , 10.36076/PPJ.2010/13/245
QiQi Zhou, G. Nicholas Verne, NMDA Receptors and Colitis: Basic Science and Clinical Implications. Reviews in Analgesia. ,vol. 10, pp. 33- 43 ,(2008) , 10.3727/154296108783994013
LK Gupta, R Gupta, CD Tripathi, N-Methyl-D-aspartate receptor modulators block hyperalgesia induced by acute low-dose morphine. Clinical and Experimental Pharmacology and Physiology. ,vol. 38, pp. 592- 597 ,(2011) , 10.1111/J.1440-1681.2011.05556.X
Gary J Bennett, Update on the Neurophysiology of Pain Transmission and Modulation: Focus on the NMDA-Receptor Journal of Pain and Symptom Management. ,vol. 19, pp. 2- 6 ,(2000) , 10.1016/S0885-3924(99)00120-7
Elahe Taghiabadi, Hossein Hosseinzadeh, Saied Sadeghi Shakib, Abbas Khadem Sameni, Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iranian Journal of Pharmaceutical Research. ,vol. 12, pp. 93- 99 ,(2013) , 10.22037/IJPR.2013.1247
Andrei B. Petrenko, Tomohiro Yamakura, Hiroshi Baba, Koki Shimoji, The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesthesia & Analgesia. ,vol. 97, pp. 1108- 1116 ,(2003) , 10.1213/01.ANE.0000081061.12235.55
Samantha M South, Stephen R Edwards, Maree T Smith, Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-Dawley rats: differences between the tail flick and hot plate nociceptive tests. Clinical and Experimental Pharmacology and Physiology. ,vol. 36, pp. 20- 28 ,(2009) , 10.1111/J.1440-1681.2008.05019.X
István Baczkó, István Leprán, Julius Gy Papp, KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. European Journal of Pharmacology. ,vol. 324, pp. 77- 83 ,(1997) , 10.1016/S0014-2999(97)00064-2
S. GRASS, O HOFFMANN, X.-J. XU, Z. WIESENFELD-HALLIN, N-methyl-D-aspartate receptor antagonists potentiate morphine's antinociceptive effect in the rat. Acta Physiologica Scandinavica. ,vol. 158, pp. 269- 273 ,(1996) , 10.1046/J.1365-201X.1996.566309000.X
Nagendra S. Singh, Rajib K. Paul, Marc C. Torjman, Irving W. Wainer, Gabapentin and (S)-pregabalin decrease intracellular D-serine concentrations in PC-12 cells. Neuroscience Letters. ,vol. 535, pp. 90- 94 ,(2013) , 10.1016/J.NEULET.2012.12.024