Rabbit model for Chlamydia pneumoniae infection.

摘要: A rabbit model was established for Chlamydia pneumoniae infection that may be helpful to understand the pathogenesis of disease in humans. Twelve, pathogen-free, 1-month-old New Zealand White rabbits were inoculated with 1.0 x 10(7) 5.0 CFU purified C. (ATCC strain VR 1310) via nasopharynx (1 died immediately postinoculation, and 11 available study). Five controls carrier buffer. Ten study demonstrated serological evidence acute (immunoglobulin G antibodies, 1:8 > 1:16), weakest response at 7 days strongest 28 days, whereas none showed any seroconversion. Study animals sacrificed batches three, on 7, 14, 21, 28, but 28. Two-thirds bronchiolitis pneumonia 14 resolution by day 21. Two demonstrated, histology, early intermediate lesions atherosclerosis: one animal (day 7) accumulation foamy macrophages (fatty streak) arch aorta, other 14) spindle cell proliferation smooth muscle cells (intermediate lesion). Focal periaortitis seen same 7). elementary bodies immunocytochemical stain lungs (n = 2), liver 3), spleen 5), aorta which corresponded lesion. cultured from aortic 1). All histopathological, immunocytochemical, cultural studies negative controls. Hence, provides a useful its complications, particularly atherosclerosis.