Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

摘要: Abstract Objective: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae both coronary heart disease cardiovascular risk factors. Objective:To Setting: General practices in Merton, Sutton, Wandsworth, south London. Subjects: 388 white London men aged 50-69. Main outcome measures: Evidence of factors infection H or C pneumoniae. Results: 47 (12.1%) had electrocardiographic evidence ischaemia infarction. 36 (76.6%) 18 (38.3%) were seropositive for pneumoniae, respectively, compared 155 (45.5%) 62 (18.2%) normal electrocardiograms. Odds ratios abnormal electrocardiograms 3.82 (95% confidence interval 1.60 9.10) 3.06 (12.33 7.01) after adjustment a range socioeconomic indicators disease. Cardiovascular that independently associated included fibrinogen concentration total leucocyte count. Seropositivity was raised malondialdehyde concentrations. Conclusions: Both are These relations not explained by wide confounding Possible mechanisms include an increase factor levels due low grade inflammatory response.