Chromosomal basis of hematologic malignancies

摘要: Publisher Summary This chapter discusses the chromosomal basis of hematologic malignancies. Major advances in cancer cytogenetics took place early 1970s with introduction both improved banding techniques and tissue culture methods. The surprising relationship unique abnormalities specific neoplasia during neoplastic development has been a prime concern. Almost all human cancers have aberrant genomic constitution, whose significance explained using chromosome bands. A definite between genetic anomalies types proliferative processes is described chapter. gain material implicated gene amplification, while complex suggest different mechanism changes, which may be responsible for Literature pertaining to changes diseases quite extensive. acute leukemias are highly heterogeneous group malignant proliferations generally classified as either lymphocytic leukemia (ALL) or nonlymphocytic (ANLL). Consistent non-Hodgkin's lymphoma (NHL) and, more importantly, these nonrandom correlated histological immunological phenotype.