THE ELECTRICAL EXCITABILITY OF ISOLATED CORTEX DURING BARBITURATE WITHDRAWAL

摘要: The susceptibility of cerebral cortex to epileptiform activity was studied in cats undergoing barbiturate withdrawal. Epileptiform afterdischarges were initiated neuronally isolated by electrical stimulation, and the threshold duration measured. In some animals, prolonged during other animals who judged be equally dependent on barbiturates their increased sensitivity pentylenetetrazol, normal range. changes responsiveness stimulation withdrawal small unreliable comparison produced chronic neuronal isolation cortex. It concluded that principal change responsible for seizures occurred subcortical structures. control depended amplitude shocks used elicit afterdischarge. bearing this observation theories regarding mechanism electrically induced paroxysmal is discussed.