Immunological stress at the maternal-foetal interface : A link between neurodevelopment and adult psychopathology

摘要: Abstract Maternal infection during pregnancy is associated with a higher incidence of mental disorders, including schizophrenia, in the offspring later life. Our recent attempt to study this link between prenatal immunological challenge and subsequent psychopathology has led establishment mouse model demonstrating emergence multiple psychotic-like phenotypes following on gestation day (GD) 9. However, little known about impact similar utero at different times pregnancy. Here, we compare efficacy identical maternal immune stimulation induced by exposure polyriboinosinic–polyribocytidilic acid (Poly(I:C)) dose 5 mg/kg (i.v.) distinct days (GD 6, 9, 13 or 17). The derived were then compared those collected from vehicle- non-treated dams two paradigms selective associative learning: latent inhibition (LI) US-pre-exposure effect (USPEE). LI deficiency was observed animals born treated Poly(I:C) GD 9 13, but not GD17. In contrast, loss USPEE equivalently seen all treatment groups, regardless times. Evaluation acute cytokine response separate cohort pregnant receiving either GD9 GD17 revealed that ratio interleukin-10/tumor necrosis factor-α elevated relative group. present report thus provides evidence reaction as well long-term pattern behavioural sequelae can be affected its precise timing further support use elucidation mechanisms involved aetiology disease process immuno-precipitated neurodevelopmental diseases, limited to, schizophrenia.