Warfarin in the secondary prevention of thromboembolism in atrial fibrillation: impact of bioavailability on costs and outcomes.

作者: Nicole Mittmann , Paul I Oh , Scott E Walker , William R Bartle

DOI: 10.2165/00019053-200422100-00005

关键词:

摘要: Background: The bioavailability of warfarin is an important factor affecting the achievement therapeutic anticoagulation. It uncertain whether less expensive generic preparations would compromise prevention thromboembolism or increase bleeding risk in patients with atrial fibrillation.

参考文章(19)
A. Laupacis, D. Feeny, P. X. Tugwell, A. S. Detsky, Tentative guidelines for using clinical and economic evaluations revisited Canadian Medical Association Journal. ,vol. 148, pp. 927- 929 ,(1993)
A. Laupacis, D. Feeny, P. X. Tugwell, A. S. Detsky, How attractive does a new technology have to be to warrant adoption and utilization? Tentative guidelines for using clinical and economic evaluations Canadian Medical Association Journal. ,vol. 146, pp. 473- 481 ,(1992)
Jeanne M. DeCara, Sheila Croze, Rodney H. Falk, Generic warfarin: a cost-effective alternative to brand-name drug or a clinical wild card? Chest. ,vol. 113, pp. 261- 263 ,(1998) , 10.1378/CHEST.113.2.261
Richard H. White, Hong Zhou, Patrick Romano, Dennis Mungall, Changes in plasma warfarin levels and variations in steady-state prothrombin times. Clinical Pharmacology & Therapeutics. ,vol. 58, pp. 588- 593 ,(1995) , 10.1016/0009-9236(95)90179-5
B S P Hellemons, M Langenberg, J Lodder, F Vermeer, H J A Schouten, T. Lemmens, J W van Ree, J A Knottnerus, Primary prevention of arterial thromboembolism in non-rheumatic atrial fibrillation in primary care: randomised controlled trial comparing two intensities of coumarin with aspirin. BMJ. ,vol. 319, pp. 958- 964 ,(1999) , 10.1136/BMJ.319.7215.958
Annette Lemche Gulløv, Birgitte Gade Koefoed, Palle Petersen, Bleeding During Warfarin and Aspirin Therapy in Patients With Atrial Fibrillation The AFASAK 2 Study JAMA Internal Medicine. ,vol. 159, pp. 1322- 1328 ,(1999) , 10.1001/ARCHINTE.159.12.1322