Genetic factors in inward vs outward personality Organizations: focus on HTR2A polymorphisms
作者： Bernardo Nardi , Francesco Piva , Chiara Turchi , Matteo Cedraro , Emidio Arimatea
DOI: 10.1016/J.QUIP.2011.04.001
关键词:
摘要: Abstract Introduction Reciprocity with primary caregivers drives subjects’ adaptive abilities towards the construction of a Personal Meaning Organization (PMO) that is useful respect to their developmental environment. Those inward personalities read environmental signals through internal activations; those outward activations It has recently been shown PMO development may also have physiological and genetic bases. Because serotonin receptor 2A gene (HTR2A) one serotoninergic genes associated personality behaviour, it expected exert an influence on development. The aim this work was explore possible correlations between HTR2A single nucleotide polymorphisms (SNPs) inward/outward PMO. Materials methods We enrolled 149 healthy, unrelated members our hospital staff (65 males, 84 females; mean ages 42 ± 10.3 37.6 ± 8.7, respectively). Each classified as having or by two trained psychotherapists using Post-Rationalist Clinical Interview self-rating questionnaires for A mini-sequencing assay used assess 20 SNPs at locus in genomic DNA samples from each participant. Results Three intronic (rs2770304, rs55948462, rs61948318) were found be rather than Conclusions These preliminary results indicate can outcome associations identified study support view attachment behaviour genetically based. This evidence clinically relevant better understanding efficacy pharmacological psychotherapeutic strategies, suggests further investigation warranted discover new variants.
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