Increased regulatory T cells in acute lymphoblastic leukaemia patients
作者： Siti-Zuleha Idris , Norfarazieda Hassan , Le-Jie Lee , Sabariah Md Noor , Raudhawati Osman
DOI: 10.1080/10245332.2015.1101965
关键词:
摘要: Introduction: Regulation in adaptive immune response balances a fine line that prevents instigation of self-damage or fall into unresponsiveness permitting abnormal cell growth. Mechanisms keep this balance check include regulatory T cells (Tregs). Tregs consist small but heterogeneous population, which may be identified by the phenotype, CD3+CD4+CD25+CD127−. The role pathogenesis cancers is thus far supported evidence increased various and contribute to poorer prognosis. also important acute leukaemias.Objective: A review literature on leukaemias was conducted were determined B-cell lymphoblastic (ALLs).Results: Studies ALL are few controversial. We observed significantly percentage (mean±SD, 9.72 ± 3.79% vs. 7.05 ± 1.74%; P = 0.047) bone marrow/peripheral blood (n = 17) compared peripheral normal controls (n = 35)...
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