Simvastatin improves spinal fusion in rats
作者： Bora Bostan , Taner Gunes , Murat Asci , Cengiz Sen , Mehmet Kelestemur
关键词:
摘要: Objective: Statins stimulate bone formation by inducing the expression of morphogenetic proteins (BMP-2). The aim our study was to investigate effects orally administered simvastatin on spinal fusion in rats. Methods: Twenty rats were randomized into a group (SF) (n=10) or and oral (SFS) (n=10). A performed between L4-L6 representing two levels. Simvastatin (120 mg/kg/day) SFS group. killed at end 12 week period. Results: Manual palpation revealed moderate fusions SF did not reveal any signs pseudoarthrosis. An average three-point bending force causing failure results 148.80±39.403 Newtons 123.80±28.479 groups, respectively (p>0.05). Histological examination better grades (mean: 9.30±0.949) than 6.80±2.044) (p=0.003). Radiographic Grade C levels 18 In group, detected one level 19. Conclusion: Our suggest that can promote be used as an adjunct procedures elderly population with high cholesterol
aott.org.tr 
sci-hub.se 参考文章(31)
P. M. HUDDLESTON, J. M. STECKELBERG, A. D. HANSSEN, M. S. ROUSE, M. E. BOLANDER, R. PATEL, Ciprofloxacin inhibition of experimental fracture healing. Journal of Bone and Joint Surgery, American Volume. ,vol. 82, pp. 161- 173 ,(2000) , 10.2106/00004623-200002000-00002
Sanjeev Patil, Graeme Holt, Nigel Raby, Alastair R. McLellan, Karen Smith, Sarah O'Kane, Graham Beastall, James F. Crossan, Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing Journal of Orthopaedic Research. ,vol. 27, pp. 281- 285 ,(2009) , 10.1002/JOR.20572
Christopher J Edwards, Tim D Spector, Statins as modulators of bone formation Arthritis Research. ,vol. 4, pp. 151- 153 ,(2002) , 10.1186/AR399
Antonio M. Gotto, John C. Larosa, The benefits of statin therapy--what questions remain? Clinical Cardiology. ,vol. 28, pp. 499- 503 ,(2005) , 10.1002/CLC.4960281103
Stefano Guizzardi, Mario Di Silvestre, Renato Scandroglio, Alessandro Ruggeri, Romolo Savini, Implants of heterologous demineralized bone matrix for induction of posterior spinal fusion in rats. Spine. ,vol. 17, pp. 701- 707 ,(1992) , 10.1097/00007632-199206000-00010
Michael J. Gonyeau, Statins and Osteoporosis: A Clinical Review Pharmacotherapy. ,vol. 25, pp. 228- 243 ,(2005) , 10.1592/PHCO.25.2.228.56954
Inneke H. Drespe, Gert K. Polzhofer, A. Simon Turner, Jonathan N. Grauer, Animal models for spinal fusion. The Spine Journal. ,vol. 5, ,(2005) , 10.1016/J.SPINEE.2005.02.013
Albert Juang Ming Yee, Hyun W. Bae, Darin Friess, Sandie M. Roth, Cari Whyne, Mark Robbin, Brian Johnstone, Jung U. Yoo, The use of simvastatin in rabbit posterolateral lumbar intertransverse process spine fusion The Spine Journal. ,vol. 6, pp. 391- 396 ,(2006) , 10.1016/J.SPINEE.2005.10.017
Teruyasu Ohno, Mitsunori Shigetomi, Koichiro Ihara, Tsunemitsu Matsunaga, Takahiro Hashimoto, Hiroo Kawano, Toshihiro Sugiyama, Shinya Kawai, Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats. Transplantation. ,vol. 76, pp. 869- 871 ,(2003) , 10.1097/01.TP.0000074992.49236.58
Bingkui Ma, Susan A. Clarke, Roger A. Brooks, Neil Rushton, The effect of simvastatin on bone formation and ceramic resorption in a peri-implant defect model Acta Biomaterialia. ,vol. 4, pp. 149- 155 ,(2008) , 10.1016/J.ACTBIO.2007.05.004