Eleven phthalate esters and di(2-ethylhexyl) adipate in one-week duplicate diet samples obtained from hospitals and their estimated daily intake

摘要: Plasticizers in duplicate diet samples obtained over 1 week were analysed order to estimate daily intake. The phthalate esters as follows: diethyl, dipropyl, dibutyl, dipentyl, dihexyl, butylbenzyl, dicyclohexyl, di(2-ethylhexyl), dioctyl, diisooctyl (mixture of isomers) and diisononyl (mixture). Di(2-ethylhexyl) adipate was also determined. Homogenized composite meals extracted with acetonitrile, lipids removed by extraction into n-hexane the acetonitrile layer cleaned using Florisil Bondesil PSA dual column. Phthalates determined GC/MS (SIM). Phthalate recovery from fortified food mixture this method 62.5-140.8%. Quality assurance assessed three laboratories indicated coefficient variance levels detected phthalates same lot below 10%. Detection limits 0.1-23 ng/g for each phthalate. One-week provided hospitals remote prefectures Japan individual meals. In all 63 samples, DEHP present at highest level among range 10-4400 ng/g. intake plasticizers estimated 519 microg DEHP/day, 86 DEHA/day, 65 DINP/day, 4.7 BBP/day. Calculated 2-day out 21 days exceeded EU TDI a person 50 kg body weight (1850 per day). Disposable PVC gloves used during preparation suspected source high content. One-day other DEHA 7% cases. High concentrations (5990 ng/g) found baby quality work. contamination PVC-tube production effectively reduced replacing tube one made stainless steel.