Stereochemistry of the myo-inositol-1-phosphate synthase reaction.
作者： M.W. Loewus , F.A. Loewus , G.U. Brillinger , H. Otsuka , H.G. Floss
DOI: 10.1016/S0021-9258(19)70191-4
关键词:
摘要: Experiments with D-glucose-6-P stereospecifically tritiated at C-6 showed that the myo-inositol-1 P synthase reaction catalyzed by both enzyme from beef testis and pollen of Lilium longiflorum proceeds stereospecific loss pro-6R incorporation pro-6S hydrogen into product. The ring closure thus occurs in a retention mode substrate, finding variance an earlier report, but agreement stereochemistry recently determined for Streptomyces flavopersicus general stereochemical operation aldolases.
sci-hub.st 参考文章(18)
J. E. G. Barnett, A. Rasheed, D. L. Corina, Partial reactions of d-glucose 6-phosphate–1 l-myoinositol 1-phosphate cyclase Biochemical Journal. ,vol. 131, pp. 21- 30 ,(1973) , 10.1042/BJ1310021
M W Loewus, Hydrogen isotope effects in the cyclization of D-glucose 6-phosphate by myo-inositol-1-phosphate synthase. Journal of Biological Chemistry. ,vol. 252, pp. 7221- 7223 ,(1977) , 10.1016/S0021-9258(19)66958-9
W R Sherman, A Rasheed, L A Mauck, J Wiecko, Incubations of testis myo-inositol-1-phosphate synthase with D-(5-18O)glucose 6-phosphate and with H218O show no evidence of Schiff base formation. Journal of Biological Chemistry. ,vol. 252, pp. 5672- 5676 ,(1977) , 10.1016/S0021-9258(17)40075-5
C.E. Snipes, G.U. Brillinger, L. Sellers, L. Mascaro, H.G. Floss, Stereochemistry of the dTDP-glucose oxidoreductase reaction. Journal of Biological Chemistry. ,vol. 252, pp. 8113- 8117 ,(1977) , 10.1016/S0021-9258(17)40946-X
CH Chen, F Eisenberg, Myoinosose-2 1-phosphate: an intermediate in the myoinositol 1-phosphate synthase reaction. Journal of Biological Chemistry. ,vol. 250, pp. 2963- 2967 ,(1975) , 10.1016/S0021-9258(19)41580-9
L. A. Mitscher, L. L. Martin, D. R. Feller, J. R. Martin, A. W. Goldstein, The biosynthesis of spectinomycin Journal of The Chemical Society D: Chemical Communications. pp. 1541- 1542 ,(1971) , 10.1039/C29710001541
Kenneth R. Hanson, Irwin A. Rose, Interpretations of enzyme reaction stereospecificity Accounts of Chemical Research. ,vol. 8, pp. 1- 10 ,(1975) , 10.1021/AR50085A001
I CHEN, F CHARALAMPOUS, Studies on the mechanism of cyclization of glucose 6-phosphate to D-inositol 1-phosphate. Biochimica et Biophysica Acta. ,vol. 136, pp. 568- 570 ,(1967) , 10.1016/0304-4165(67)90017-7
Mary W. Loewus, F. Loewus, The Isolation and Characterization of d-Glucose 6-Phosphate Cycloaldolase (NAD-Dependent) from Acer pseudoplatanus L. Cell Cultures: Its Occurrence in Plants Plant Physiology. ,vol. 48, pp. 255- 260 ,(1971) , 10.1104/PP.48.3.255
Frank A. Loewus, Stanley Kelly, Conversion of glucose to inositol in parsley leaves Biochemical and Biophysical Research Communications. ,vol. 7, pp. 204- 208 ,(1962) , 10.1016/0006-291X(62)90175-4