The Immune Modulating Properties of Mucosal-Associated Invariant T Cells

摘要: Mucosal-associated invariant T (MAIT) cells are unconventional lymphocytes that express a semi-invariant cell receptor (TCR) recognizing microbial vitamin B metabolites presented by the highly conserved major histocompatibility complex (MHC) class I like molecule, MR1. The produced several commensal and pathogenic bacteria yeast, but not viruses. Nevertheless, viral infections can trigger MAIT activation in TCR-independent manner, through release of pro-inflammatory cytokines antigen-presenting (APCs). belong to innate family with memory phenotype, which allows them rapidly Interferon (IFN)-γ, tumor necrosis factor (TNF)-α, some circumstances Interleukin (IL)-17 IL-10, exerting an immunomodulatory role on ensuing immune response, akin iNKT γδ cells. Recent studies implicate variety inflammatory, autoimmune diseases, cancer. In addition, analysis transcriptome activated different experimental conditions, important function tissue repair control homeostasis has emerged, shared other innate-like this review, we discuss these recent findings, focussing understanding molecular mechanisms underpinning effector health disease, ultimately will aid clinically harnessing unique, donor-restricted subtype.