Intracellular Pathogen Detection by RIG-I-Like Receptors
作者： Evelyn Dixit , Jonathan C. Kagan
DOI: 10.1016/B978-0-12-410524-9.00004-9
关键词:
摘要: The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA thus responsible intracellular surveillance infection. RLR signaling requires the adapter protein MAVS induce type I interferon, interferon-stimulated genes, proinflammatory cytokines. This review focuses on molecular cell biological requirements signal transduction.
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