Molecular genetics of pancreatic intraepithelial neoplasia.

作者: Georg Feldmann , Robert Beaty , Ralph H. Hruban , Anirban Maitra

DOI: 10.1007/S00534-006-1166-5

关键词:

摘要: Background Recent evidence suggests that noninvasive precursor lesions, classified as pancreatic intraepithelial neoplasia (PanIN), can progress to invasive cancer. This review will discuss the major genetic alterations in PanIN lesions.

参考文章(84)
Susan C. Abraham, Tsung-Teh Wu, David S. Klimstra, Laura S. Finn, Jae-Hyuk Lee, Charles J. Yeo, John L. Cameron, Ralph H. Hruban, Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas: Frequent Alterations in the APC/β-Catenin Pathway and Chromosome 11p American Journal of Pathology. ,vol. 159, pp. 1619- 1627 ,(2001) , 10.1016/S0002-9440(10)63008-8
Michael Goggins, Ralph H. Hruban, Scott E. Kern, BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications. American Journal of Pathology. ,vol. 156, pp. 1767- 1771 ,(2000) , 10.1016/S0002-9440(10)65047-X
D S Klimstra, D S Longnecker, K-ras mutations in pancreatic ductal proliferative lesions. American Journal of Pathology. ,vol. 145, pp. 1547- 1550 ,(1994)
Carlos Caldas, Scott E Kern, None, K-ras mutation and pancreatic adenocarcinoma. International Journal of Pancreatology. ,vol. 18, pp. 1- 6 ,(1995) , 10.1007/BF02825415
Giulio Draetta, Michele Pagano, Cell cycle control and cancer. Harvey Lectures. ,vol. 96, pp. 73- 92 ,(2000)
Jussi Taipale, Philip A. Beachy, The Hedgehog and Wnt signalling pathways in cancer Nature. ,vol. 411, pp. 349- 354 ,(2001) , 10.1038/35077219
Elizabeth M. Jaffee, Ralph H. Hruban, Tara Ellingham, Karen M. Hauda, Patricia P. Long, Charles J. Yeo, Constance A. Griffin, Stefan K. Bohlander, Laura A. Morsberger, Consistent Chromosome Abnormalities in Adenocarcinoma of the Pancreas Cancer Research. ,vol. 55, pp. 2394- 2399 ,(1995)
Takayuki Shiomi, Yasunori Okada, MT1-MMP and MMP-7 in invasion and metastasis of human cancers. Cancer and Metastasis Reviews. ,vol. 22, pp. 145- 152 ,(2003) , 10.1023/A:1023039230052
Ralph H. Hruban, Irmgard Schwarte-Waldhoff, Joseph Geradts, Mieke Schutte, Wolff Schmiegel, Stephen B. Baylin, Werner Hilgers, Stephan A. Hahn, Scott E. Kern, James G. Herman, Rob Maynard, Christopher A. Moskaluk, Sridhar K. Rabindran, Abrogation of the Rb/p16 Tumor-suppressive Pathway in Virtually All Pancreatic Carcinomas Cancer Research. ,vol. 57, pp. 3126- 3130 ,(1997)
Frank Gansauge, Susanne Gansauge, Marco Ramadani, Nobohiko Harada, Hans G. Beger, Bettina Rau, Heike Stobbe, Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis. Cancer Research. ,vol. 57, pp. 1634- 1637 ,(1997)