Optimization of preparation of matrix pellets containing ethylcellulose

摘要: Abstract The aim of this study was to investigate the effects parameters spheronization and nature wetting liquid on properties matrix pellets prepared by extrusion spheronization. Ethylcellulose used as a former, microcrystalline cellulose filler, atenolol model active agent, water water–ethanol mixture liquids. formation interactions components were evaluated via mechanical, dissolution morphological studies pellets. A factorial design determine factors. It concluded that significant exerted not only operational parameters, but also liquid. breaking hardness revealed ethanol in caused changes wettability consequently structure. This explained comparison relative importance alterations induced preferable dissolution, because possibility burst effect first phase can then be avoided. However, it is favourable concerns sphericity mechanical