Adhesion GPCRs in Tumorigenesis.
作者： Gabriela Aust , Dan Zhu , Erwin G. Van Meir , Lei Xu
DOI: 10.1007/978-3-319-41523-9_17
关键词:
摘要: Alterations in the homeostasis of several adhesion GPCRs (aGPCRs) have been observed cancer. The main cellular functions regulated by aGPCRs are cell adhesion, migration, polarity, and guidance, which all highly relevant to tumor biology. Expression can be induced, increased, decreased, or silenced stromal cells microenvironment, including fibroblasts endothelial and/or immune cells. For example, ADGRE5 (CD97) ADGRG1 (GPR56) show increased expression many cancers, initial functional studies suggest that both for migration invasion. also impact regulation angiogenesis releasing soluble fragments following cleavage their extracellular domain (ECD) at conserved GPCR-proteolytic site (GPS) other more distal sites as typical ADGRB (BAI) family. Interrogation silico cancer databases suggests alterations aGPCR members provides impetus further exploration potential role Integration knowledge on expression, regulation, function tumorigenesis is currently spurring first preclinical examine related pathways therapeutic targets.
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