The association of MDM2 c.346G>A genetic variant with the risk of osteosarcoma in Chinese.
作者： Zhaohui Hu , Ningning Li , Xiangtao Xie , Renjie Jiang
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摘要: Previous studies suggest that the MDM2 gene is one of most important candidate genes for influencing risk osteosarcoma. This study aims to investigate potential association c.346G>A genetic variant with osteosarcoma in Chinese. A total 738 subjects were recruited this study. The genotypes detected by created restriction site–polymerase chain reaction. Our data associated increased homozygote comparison (AA vs. GG: odds ratio [OR]=2.36, 95% confidence interval [CI] 1.30–4.28, χ2=8.35, p=0.004), recessive model GA/GG: OR=2.32, CI 1.30–4.13, χ2=8.50, and allele (A G: OR=1.27, 1.01–1.60, χ2=4.34, p=0.037). Results from indicated allele-A genotype-AA could be an factor susceptibility might used as a...
sci-hub.se 参考文章(23)
Zhengrong Yuan, Jiao Li, Junya Li, Xue Gao, Shangzhong Xu, SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene Molecular Biology Reports. ,vol. 40, pp. 7- 12 ,(2013) , 10.1007/S11033-012-1934-Z
Lisa Mirabello, Rebecca J. Troisi, Sharon A. Savage, Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program Cancer. ,vol. 115, pp. 1531- 1543 ,(2009) , 10.1002/CNCR.24121
Jinshan He, Jingcheng Wang, Daxin Wang, Shanhe Dai, Tangyun Yv, Pengtao Chen, Renshi Ma, Chunyv Diao, Guohua Lv, Association analysis between genetic variants of MDM2 gene and osteosarcoma susceptibility in Chinese. Endocrine Journal. ,vol. 60, pp. 1215- 1220 ,(2013) , 10.1507/ENDOCRJ.EJ13-0260
Salvador Mejia-Guerrero, Michael Quejada, Nalan Gokgoz, Mona Gill, Robert K. Parkes, Jay S. Wunder, Irene L. Andrulis, Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes, Chromosomes and Cancer. ,vol. 49, pp. 518- 525 ,(2010) , 10.1002/GCC.20761
Carolina Salinas-Souza, Antonio S Petrilli, Silvia RC de Toledo, None, Glutathione S-transferase polymorphisms in osteosarcoma patients. Pharmacogenetics and Genomics. ,vol. 20, pp. 507- 515 ,(2010) , 10.1097/FPC.0B013E32833CAA45
Yang Liu, Bitao Lv, Zhimin He, Yujia Zhou, Carrie Han, Guodong Shi, Rui Gao, Ce Wang, Lili Yang, Haihan Song, Wen Yuan, Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma PLoS ONE. ,vol. 7, pp. e41610- ,(2012) , 10.1371/JOURNAL.PONE.0041610
Zhengrong Yuan, Junya Li, Jiao Li, Xue Gao, Huijiang Gao, Shangzhong Xu, None, Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Molecular Biology Reports. ,vol. 40, pp. 1947- 1954 ,(2013) , 10.1007/S11033-012-2251-2
Jinshan He, Jingcheng Wang, Daxin Wang, Shanhe Dai, Tangyun Yv, Pengtao Chen, Renshi Ma, Chunyv Diao, Guohua Lv, Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population. Endocrine. ,vol. 45, pp. 325- 330 ,(2014) , 10.1007/S12020-013-0050-8
A. Haliassos, J.C. Chomel, L. Tesson, M. Baudis, J. Kruh, J.C. Kaplan, A. Kitzis, Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Research. ,vol. 17, pp. 3606- 3606 ,(1989) , 10.1093/NAR/17.9.3606
Wen Wang, Jian Wang, Haihan Song, Jie Liu, Bao Song, Xuecheng Cao, Cytotoxic T-Lymphocyte Antigen-4 +49G/A Polymorphism Is Associated with Increased Risk of Osteosarcoma Genetic Testing and Molecular Biomarkers. ,vol. 15, pp. 503- 506 ,(2011) , 10.1089/GTMB.2010.0264