Some bioengineering considerations for tissue engineering of articular cartilage.

摘要: The mechanism(s) by which chondrocytes convert physical stimuli to intracellular signals, in turn direct cell activities, represents an area of intense current orthopaedic tissue engineering research. This report is aimed at providing overview some biomechanical factors that are required for pursuing this type Two specific aspects cartilage addressed: (1) how does the function biomechanically; and (2) what nature inside articular cartilage. By focusing on effects inhomogeneities material properties, a description mechanical electrochemical events (the stimuli) would occur during loading presented. simple common tests considered: permeation confined compression. Theoretical analyses using appropriate constitutive laws biphasic triphasic theories) reveal details surface loadings converted signals extracellular matrix hydraulic osmotic pressures, fluid, solute ion flows, deformations, electrical fields. shown be able significantly change within matrix, thus environments around chondrocytes. Material arising from flow interstitial fluid through porous permeable also discussed. In authors' view, charged together with associated ions, collectively can thought as signal transducer. Knowledge their variations time location after loading, essential understanding transduction