Clinical significance of methylation of E-cadherin and p14ARF gene promoters in skin squamous cell carcinoma tissues.

摘要: Epigenetic regulation of genes by DNA methylation contributes to cancer. The present study sought identify changes in the promoters E-cadherin and p14ARF, two with potential cancer roles promoting skin squamous cell carcinoma. Skin carcinoma specimens were collected from 40 patients normal tissues 30 individuals as controls. Promoter was detected for p14ARF methylation-specific PCR. Correlations between or clinicopathological parameters analyzed Spearman rank test. Methylation (37.5%) (60.0%) significantly more common than tissue (10.0 6.7%, respectively; P < 0.05). Additionally, positively correlated within (r = 0.422, 0.007). Furthermore, these gene differentiation, lymph node metastasis, clinical stage (P Aberrant may promote occurrence progression