作者: Franziska Michor , Martin A. Nowak , Steven A. Frank , Yoh Iwasa
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摘要: Tissues of multicellular organisms consist stem cells and differentiated cells. Stem divide to produce new or Differentiated We show that such a tissue design can reduce the rate fixation mutations increase net proliferation It has, however, no consequence for neutral mutations. calculate optimum relative abundance minimizes generating cancer There is critical fraction cell divisions required stochastic elimination ('wash out')