High expression of CD39/ENTPD1 in malignant epithelial cells of human rectal adenocarcinoma

摘要: The ectonucleotidase CD39 is pivotal in the conversion of immunostimulatory adenosine triphosphate (ATP) into immunosuppressive which potently inhibits host immune responses against cancer. This study investigated expression level and prognostic significance human rectal adenocarcinoma. Our data demonstrated that staining strongly marked malignant epithelial cells where protein messenger RNA (mRNA) levels were significantly increased compared with paracancerous controls. In addition to primary tumors, was also abundantly expressed liver metastases tumor-draining lymph nodes from metastatic Although patients higher density tumor more likely have favorable characteristics (early TNM N stages) overall survival, singular parameter cannot be used as an independent factor for predicting patients' prognosis. Intriguingly, combined analysis CD73 efficient foretell patient's outcome but decreased displayed a worst Taken together, current revealed adenocarcinoma express may play potential role invasion metastasis. high correlated clinical outcome, combination better value.