High expression of CD73 as a poor prognostic biomarker in human colorectal cancer.
作者： Xian-Rui Wu , Xiao-Sheng He , Yu-Feng Chen , Rui-Xue Yuan , Yang Zeng
DOI: 10.1002/JSO.23056
关键词:
摘要: Background and Objectives To investigate the expression dynamics of CD73 its prognostic significance in human colorectal cancer (CRC). Methods CD73 were detected by Western blotting. Immunohistochemistry was used to examine CRC tissues from two independent cohorts tissue microarrays. The optimal cutpoint assessed X-tile program. Results Western blotting analysis demonstrated that significantly higher than normal tissues. According program, for high determined when index more 5.9. High observed 44.8% 50.4% training validation cohorts, respectively. Overexpression correlated with tumor differentiation, nodal status, American Joint Committee on Cancer stage. Patients had a poorer overall survival rate compared patients low both cohorts. In multivariate Cox regression analysis, overexpression proven be an biomarker CRC. Conclusions High can useful predicting poor CRC. J. Surg. Oncol. 2012; 106:130–137. © 2012 Wiley Periodicals, Inc.
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