NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.

摘要: According to the World Health Organization, bladder cancer is seventh most common among men in world. The current treatments for this malignancy are not efficient prevent recurrence and progression of tumors. Then, researches continue looking better therapeutic targets which can end up new more treatments. One recent findings was identification that purinergic system involved tumorigenesis. ectonucleotidases, mainly ecto-5′-nucleotidase/CD73 have been revealed as players malignity. In work, we investigated NTPDase3 expression vivo. Bladder tumor induced mice by addition 0.05 % N-butyl-N-(hydroxybutyl)-nitrosamine (BBN) drinking water 4, 8, 12, 18, 24 weeks. After period, bladders were removed histopathology analysis immunofluorescence assays. animals has received BBN had alterations, inflammation, initial times induction. 18 weeks, mice’s developed histological alterations similar human transitional cell carcinoma. cancerous urothelium, from 24 weeks, presented a weak immunostaining NTPDase3, contrast an increased ecto-5′-nucleotidase/CD73. altered herein adds further evidence support idea ectonucleotidases tumorigenesis reinforce future biomarker and/or target pharmacological therapy cancer.