Persistence of pain in humans and other mammals

摘要: Evolutionary models of chronic pain are relatively undeveloped, but mainly concern dysregulation an efficient acute defence, or false alarm. Here, a third possibility, mismatch with the modern environment, is examined. In ancestral human and free-living animal environments, survival needs urge return to activity during recovery, despite pain, environments allow humans domesticated animals prolonged inactivity after injury. This review uses research literature compare other mammals, who share neurophysiology, on risk factors for persistence, behaviours associated responses conspecifics behaviours. The mammal populations studied laboratory rodents in research, farm companion veterinary observations captive primates. Beyond rodent models, there virtually no evidence mammals. Since sparse, it hard conclude that does not occur, its apparent absence compatible hypothesis. article part Theo Murphy meeting issue 'Evolution mechanisms behaviour important pain'.