Synergy of subgroup J avian leukosis virus and Eimeria tenella to increase pathogenesis in specific-pathogen-free chickens
作者： Ning Cui , Qi Wang , Wenyan Shi , Linzhen Han , Jiazhong Wang
DOI: 10.1016/J.VETIMM.2016.06.001
关键词:
摘要: To investigate the effects of co-infections subgroup J avian leukosis virus (ALV-J) and Eimeria tenella on pathogenesis in specific-pathogen-free (SPF) white leghorn chickens, groups chickens were infected with ALV-J strain NX0101 at one day age or E. 14 days both. The control group was left uninfected mock-inoculated phosphate buffer saline (PBS). Mortality rates, body weights, cecal lesions, viremia each evaluated. Immune status evaluated by measuring several parameters: immune organ weight/body weight index, specific humoral responses to inactivated NDV vaccine inoculated tenella, proportions blood CD3+CD4+ CD3+CD8α+ lymphocytes transcriptional levels cytokines tonsils. results show that induced a higher mortality rate lower SPF compared single-pathogen infection. In co-infected accelerated disease symptoms extended viremia. Thymus atrophy, decrease response pathogens vaccine, modifications lymphocyte sub-populations cytokine disorders found pathogen alone controls. We underline synergy between increasing chickens.
sci-hub.se 参考文章(29)
J. R. Young, C.-L. H. Chen, M. J. H. Ratcliffe, T. F. Davison, C. A. Tregaskes, E. Paramithiotis, Fan-Kun Kong, Identification and analysis of the expression of CD8 alpha beta and CD8 alpha alpha isoforms in chickens reveals a major TCR-gamma delta CD8 alpha beta subset of intestinal intraepithelial lymphocytes. Journal of Immunology. ,vol. 154, pp. 4485- 4494 ,(1995)
Zhizhong Cui, Yan Du, Zhi Zhang, R. F. Silva, Comparison of Chinese field strains of avian leukosis subgroup J viruses with prototype strain HPRS-103 and United States strains Avian Diseases. ,vol. 47, pp. 1321- 1330 ,(2003) , 10.1637/6085
Joseph J. Giambrone, Wayne I. Anderson, W. MalColm Reid, Caswell S. Eidson, Effect of Infectious Bursal Disease on the Severity of Eimeria tenella Infections in Broiler Chicks Poultry Science. ,vol. 56, pp. 243- 246 ,(1977) , 10.3382/PS.0560243
Yanni Gao, Yongzhen Liu, Xiaolu Guan, Xiaofei Li, Bingling Yun, Xiaole Qi, Yongqiang Wang, Honglei Gao, Hongyu Cui, Changjun Liu, Yanping Zhang, Xiaomei Wang, Yulong Gao, Differential expression of immune-related cytokine genes in response to J group avian leukosis virus infection in vivo. Molecular Immunology. ,vol. 64, pp. 106- 111 ,(2015) , 10.1016/J.MOLIMM.2014.11.004
Arnaud Didierlaurent, John Goulding, Tracy Hussell, The impact of successive infections on the lung microenvironment. Immunology. ,vol. 122, pp. 457- 465 ,(2007) , 10.1111/J.1365-2567.2007.02729.X
Karin Sandelini, T. Estola, Occurrence of different subgroups of avian leukosis virus in Finnish poultry. Avian Pathology. ,vol. 3, pp. 159- 168 ,(1974) , 10.1080/03079457409353828
Joyce Johnson, W.Malcolm Reid, Anticoccidial drugs: Lesion scoring techniques in battery and floor-pen experiments with chickens Experimental Parasitology. ,vol. 28, pp. 30- 36 ,(1970) , 10.1016/0014-4894(70)90063-9
H.S Lillehoj, Role of T lymphocytes and cytokines in coccidiosis International Journal for Parasitology. ,vol. 28, pp. 1071- 1081 ,(1998) , 10.1016/S0020-7519(98)00075-7
Anita Haug, Anne-Gerd Gjevre, Eystein Skjerve, Magne Kaldhusdal, A survey of the economic impact of subclinical Eimeria infections in broiler chickens in Norway. Avian Pathology. ,vol. 37, pp. 333- 341 ,(2008) , 10.1080/03079450802050705
Jian Jun Zhang, Li Xia Wang, Wen Ke Ruan, Jian An, Investigation into the prevalence of coccidiosis and maduramycin drug resistance in chickens in China Veterinary Parasitology. ,vol. 191, pp. 29- 34 ,(2013) , 10.1016/J.VETPAR.2012.07.027