Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years

摘要: Abstract Background & Aims: Primary eosinophilic esophagitis is a chronic, increasingly recognized, interleukin 5-driven inflammatory disorder of the esophagus. The leading symptom in adults uniform attacks dysphagia, and established histologic sign dense infiltration esophageal epithelium. Before this study, natural course had not been defined information regarding potential long-term risks was lacking. Methods: This prospective case series included 30 adult patients with (22 men 8 women; mean age, 40.6 years) whose diagnosis made >1 year before study debut based on typical history, consistent endoscopic abnormalities, epithelium >24 eosinophils/high-power field. After 7.2 years, underwent comprehensive follow-up examination. Results: All survived period good health stable nutritional state. Dysphagia persisted 29 patients, exerting major negative effect socioprofessional activities 1 patient minor impact 15. Attacks dysphagia were more frequent blood eosinophilia or pronounced alterations. all symptomatic but cell numbers spontaneously decreased significantly (78.7 vs. 40.3 cells/high-power field). process evoked fibrosis lamina propria did spread to stomach duodenum. No evolved hypereosinophilic syndrome. Conclusions: Eosinophilic esophagitis, primary chronic disease restricted esophagus, leads persistent structural alterations does To date, no malignant has associated disease.