How T Cells Single Out Tumor Cells: “And That Has Made All the Difference…”

摘要: It is now beyond doubt that different human tumor types can be recognized by the immune system and cytotoxic T cells are a key player in this process. For long, efforts to understand influence such tumor-specific T-cell reactivity have focused on tumor-associated “self-antigens” also expressed other tissues. However, many of tumors with high prevalence characterized large number mutations alter open reading frames, thereby leading presentation neo-antigens foreign system. Until recently, fact majority cancer patient specific prevented exploit repertoire immunotherapy. recent work has drastically altered situation.