Vinorelbine is an active antiproliferative agent in pretreated advanced breast cancer patients: a phase II study.

摘要: PURPOSETo evaluate the efficacy and toxicity of single-agent vinorelbine (VNB), a semisynthetic vinca alkaloid, in patients with breast cancer previously treated other chemotherapeutic regimens for metastatic disease.PATIENTS AND METHODSSixty-seven 70 assessable disease entered onto study were assessable. The main characteristics as follows: median age, 60 years (range, 41 to 77); performance status (PS; Karnofsky score), 90 100); number previous given--one 17, two 27, three eight, four two, five one patient. dominant sites metastasis viscera 40, bone 16, soft tissues 11 patients. VNB was administered beginning dose 20 mg/m2 by 60-minute intravenous (iv) infusion weekly, escalation up 25 if first courses well tolerated. treatment continued until progression.RESULTSOverall, 845 given (median, 10; r...