Iron in Brain Function and Dysfunction with Emphasis on Parkinson’s Disease

摘要: Metals such as lead, zinc, copper, aluminum and manganese have been implicated in neuropsychiatric disorders. However, until fairly recently the role of iron brain function was rather obscure, because little attention paid to its metabolism brain. It is now apparent that maintenance homoeostasis important for normal functioning his organ. Most studies directed towards cognitive attentional deficit resulting from nutritional deficiency. Evidence so far suggests subsensitivity striatal dopamine neurotransmission. By contrast selective increase free substantia nigra pars compacta parkinsonian brains thought initiate oxidative stress, iron-induced liberation cytotoxic oxygen radicals. Such radicals are known promote membrane fluidity, alteration cellular calcium homoeostasis, lipid peroxidation finally cell death systemic organs. supporting similar processes being responsible nigrostriatal neuron degeneration Parkinson's disease becoming available. possibilities afford development neuroprotective drugs a means retard progression this disorder. These include other monoamine oxidase B inhibitors, chelators with ability cross blood-brain barrier, channel antagonists mitochondrial electron transport system protectors.