Prolonged Apnea in Infant Monkeys Resulting From Stimulation of Superior Laryngeal Nerve

摘要: We measured characteristics of apnea resulting from electrical stimulation the superior laryngeal nerve (SLN) in 28 anesthetized infant monkeys ranging a gestational age 141 days to 49 postterm and four adult monkeys. Progressive reduction ventilation accompanied weak suprathreshold SLN stimulation. Poststimulus followed stronger Apnea duration was directly proportional stimulus duration, provided that intensity at least 1.5 X threshold. periods were briefer older infants did not occur adults. Pao2 measurements animals showed lower values associated with longer poststimulus episodes. Upper airway resistance obtained subglottal cannula revealed glottal closure transiently onset stimulation, but degree diminished during course present subsequent period apnea. The parameters determine specific changes cardiovascular functions independently their respiratory effects. results suggest brief afferent input may have prolonged effects on regulation infants. These persisting be an important consideration sudden death syndrome mechanisms.