Application of molecular biology to mental illness. Analysis of genomic DNA and brain mRNA.

摘要: Techniques in molecular biology and genetics have made it possible to systematically study gene effects human disease. The number of clusters specifically encoding brain structure function is probably about 1,600 or half all clusters. Evolutionary such as linkage disequilibrium conservation exons (DNA structural proteins) well the fact that there are a tractable involved, tend make quite likely DNA pathology variation (polymorphism) predisposing mental illness can be detected. Genes involved detected either by studying obtained from blood samples (genomic DNA) directly analysis mRNA proteins suitable cell tissue preparations. expression still its infancy, nevertheless some hints non-poly-adenylated mRNAs may important development certain transcribed sequences specific role brain. advantage genomic use association multiply affected families will, end, almost certainly yield positive result for disease with substantial genetic input. Analysis products tissues could theory detect genes but approach will also identify secondarily process. Differentiation primarily causing those carried out using candidate markers families.