Preparation and Solid-State Characterization of Inclusion Complexes Formed Between Miconazole and Methyl-β-Cyclodextrin
作者： Andreza Ribeiro , Ana Figueiras , Delfim Santos , Francisco Veiga
DOI: 10.1208/S12249-008-9143-8
关键词:
摘要: The aim of this study is to confirm the formation inclusion complexes between miconazole (MCZ) and two derivatives beta-cyclodextrin, methyl-beta-cyclodextrin (MβCD) 2-hydroxypropyl-beta-cyclodextrin (HPβCD) in aqueous solution by phase solubility studies. Inclusion with MβCD solid state were then prepared different methods, i.e., kneading, coevaporation (COE), spray-drying (SD), lyophilization (LPh). physicochemical properties these subsequently studied means differential scanning calorimetry, Fourier transform infrared spectroscopy, electron microscopy, X-ray diffraction techniques. Phase diagrams HPβCD classified as AP type, indicating 1:1 1:2 stoichiometric complexes. apparent stability constants (KS) calculated from diagram 145.69 M−1 (K1:1) 11.11 (K1:2) for 126.94 2.20 HPβCD. method preparation was shown greatly affect formed complex. Hence, LPh, SD, COE methods produce true MCZ MβCD. In contrast, crystalline drug still clearly detectable kneaded (KN) product.
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paperity.org参考文章(34)
Kennath A. Connors, Cyclodextrins and their industrial uses: Dominique Duchêne (Editor), Editions de Santé, 19 rue Louis-le-Grand, 75002 Paris, France, 1987, 448 pages, ISBN 2-86411-019-9. Journal of Controlled Release. ,vol. 7, pp. 88- 89 ,(1988) , 10.1016/0168-3659(88)90086-7
Valentine J. Stella, Roger A. Rajewski, Cyclodextrins: Their Future in Drug Formulation and Delivery Pharmaceutical Research. ,vol. 14, pp. 556- 567 ,(1997) , 10.1023/A:1012136608249
Jette Jacobsen, Simon Bjerregaard, Morten Pedersen, Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity--drug supersaturation, toxicity on TR146 cells and release from a delivery system. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 48, pp. 217- 224 ,(1999) , 10.1016/S0939-6411(99)00043-0
Ranjit Madhukar Bidhe, Sangita Ghosh, Acute and subchronic (28-day) oral toxicity study in rats fed with novel surfactants Aaps Journal. ,vol. 6, pp. 7- 16 ,(2004) , 10.1208/PS060214
M. Charoenchaitrakool, F. Dehghani, N.R. Foster, Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-β-cyclodextrin International Journal of Pharmaceutics. ,vol. 239, pp. 103- 112 ,(2002) , 10.1016/S0378-5173(02)00078-9
Laura Ribeiro, Thorsteinn Loftsson, Domingos Ferreira, Francisco Veiga, Investigation and Physicochemical Characterization of Vinpocetine-Sulfobutyl Ether β-Cyclodextrin Binary and Ternary Complexes CHEMICAL & PHARMACEUTICAL BULLETIN. ,vol. 51, pp. 914- 922 ,(2003) , 10.1248/CPB.51.914
Marcílio S. S. Cunha-Filho, Bruno Dacunha-Marinho, Juan J. Torres-Labandeira, Ramón Martínez-Pacheco, Mariana Landin, Characterization of β-lapachone and methylated β-cyclodextrin solid-state systems Aaps Pharmscitech. ,vol. 8, ,(2007) , 10.1208/PT0803060
Ana Figueiras, Rui A. Carvalho, Laura Ribeiro, Juan J. Torres-Labandeira, Francisco J.B. Veiga, Solid-state characterization and dissolution profiles of the inclusion complexes of omeprazole with native and chemically modified β-cyclodextrin European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 67, pp. 531- 539 ,(2007) , 10.1016/J.EJPB.2007.03.005
María D. Veiga, Paloma J. Díaz, Fakhrul Ahsan, Interactions of griseofulvin with cyclodextrins in solid binary systems Journal of Pharmaceutical Sciences. ,vol. 87, pp. 891- 900 ,(1998) , 10.1021/JS970233X
M. Narender Reddy, Tasneem Rehana, S. Ramakrishna, K. P. R. Chowdary, Prakash V. Diwan, β-cyclodextrin complexes of celecoxib: Molecular-modeling, characterization, and dissolution studies Aaps Pharmsci. ,vol. 6, pp. 68- 76 ,(2004) , 10.1208/PS060107