Metaplastic Breast Cancer: Clinical Overview and Molecular Aberrations for Potential Targeted Therapy

作者: Sausan Abouharb , Stacy Moulder

DOI: 10.1007/S11912-014-0431-Z

关键词:

摘要: Metaplastic breast cancer is a rare subtype of invasive mammary carcinoma, with an aggressive behavior and usually poor outcome. Responses to systemic chemotherapy are suboptimal compared patients standard ductal carcinoma. Limited data available in regards best treatment modalities, including chemotherapy. This review gives overview metaplastic its clinical pathologic characteristics, addition strategies, trials, future directions.

参考文章(56)
Böcker W, [WHO classification of breast tumors and tumors of the female genital organs: pathology and genetics]. Pathology Research and Practice. ,vol. 86, pp. 116- 119 ,(2002)
Ann Lii Cheng, Sung Hsin Kuo, Chiun Sheng Huang, Chi Long Chen, Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer. Anticancer Research. ,vol. 20, pp. 2219- 2222 ,(2000)
V Eusebi, M P Foschini, R E Dina, Sarcomatoid neoplasms of the breast: proposed definitions for biphasic and monophasic sarcomatoid mammary carcinomas. Seminars in Diagnostic Pathology. ,vol. 10, pp. 128- 136 ,(1993)
Soo Youn Bae, Se Kyung Lee, Min Young Koo, Sung Mo Hur, Min-Young Choi, Dong Hui Cho, Sangmin Kim, Jun-Ho Choe, Jeong Eon Lee, Jung-Han Kim, Jee Soo Kim, Seok Jin Nam, Jung-Hyun Yang, None, The prognoses of metaplastic breast cancer patients compared to those of triple-negative breast cancer patients. Breast Cancer Research and Treatment. ,vol. 126, pp. 471- 478 ,(2011) , 10.1007/S10549-011-1359-8
R.J. Middlehurst, C.W. Blackburn, P. Sloan, Spindle-cell carcinoma: a case report. British Journal of Oral & Maxillofacial Surgery. ,vol. 28, pp. 114- 116 ,(1990) , 10.1016/0266-4356(90)90136-9
Rebecca Leddy, Abid Irshad, Tihana Rumboldt, Abbie Cluver, Amy Campbell, Susan Ackerman, Review of metaplastic carcinoma of the breast: imaging findings and pathologic features. Journal of clinical imaging science. ,vol. 2, pp. 21- 21 ,(2012) , 10.4103/2156-7514.95435
Florian Karreth, David A. Tuveson, Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis. Cancer Biology & Therapy. ,vol. 3, pp. 1058- 1059 ,(2004) , 10.4161/CBT.3.11.1302
Joan A. Jacobson, David N. Danforth, Kenneth H. Cowan, Teresa d'Angelo, Seth M. Steinberg, Lori Pierce, Marc E. Lippman, Allen S. Lichter, Eli Glatstein, Paul Okunieff, Ten-Year Results of a Comparison of Conservation with Mastectomy in the Treatment of Stage I and II Breast Cancer The New England Journal of Medicine. ,vol. 332, pp. 907- 911 ,(1995) , 10.1056/NEJM199504063321402
G M Tse, P H Tan, T C Putti, P C W Lui, B Chaiwun, B K B Law, Metaplastic carcinoma of the breast: a clinicopathological review Journal of Clinical Pathology. ,vol. 59, pp. 1079- 1083 ,(2006) , 10.1136/JCP.2005.030536
S K Patterson, J A Tworek, M A Roubidoux, M A Helvie, H A Oberman, Metaplastic carcinoma of the breast: mammographic appearance with pathologic correlation. American Journal of Roentgenology. ,vol. 169, pp. 709- 712 ,(1997) , 10.2214/AJR.169.3.9275883