Risk Factors Associated with Recurrence in Patients with Solid Pseudopapillary Tumors of the Pancreas

摘要: Context Solid pseudopapillary tumors (SPT) are rare, generally low grade pancreatic neoplasms that occasionally display malignant behavior. Objective To analyze the clinical and pathological features associated with increased risk of recurrence SPT. Methods Cohort study patients SPT who underwent resection primary tumor in selected cases metastatic disease from 1999-2013 at a single tertiary care Hepatopancreatobiliary center. Risk factors for were statistically analyzed. Results There 32 patients. The mean age was 35.65 years (standard deviation: 12.26), 26/32, 81.25% female. Median size resected 4.7cm (1.1-14.5). Most solid cystic (22/32, 68.75%), encapsulated (27/32, 84.4%) located body or tail 68.75%). All displayed strong β-catenin, cyclin D1, CD56, progesterone receptor staining loss E-cadherin. stained positive vimentin (15/16, 93.75%) CD10 (17/18, 94.4%). follow-up 43 months (range: 3-207); 3/32, 9.38% recurred (all after 5-years curative resection) 1 died by end period, 11 diagnosis. Patients developed recurrences ( n =3) more commonly had synchronous metastases presentation P =0.006), lymphovascular invasion =0.04) capsule =0.08) compared to those did not have recurrence. Conclusions Lymphovascular invasion, local aggressive Since may occur >5 resection, this high-risk group should undergo extended follow-up. Progression is slow, therefore, liver can offer long-term survival. Image: Vimentin .