Are long-lasting insecticide-treated bednets and water filters cost-effective tools for delaying HIV disease progression in Kenya?

摘要: Background : Co-infection with malaria and other infectious diseases has been shown to increase viral load accelerate HIV disease progression. A recent study in Kenya demonstrated that providing long-lasting insecticide-treated bednets (LLIN) water filters (WF) HIV-positive adults CD4 >350 cells/mm 3 significantly reduced Design We conducted a cost analysis estimate the potential net financial savings gained by delaying progression increasing time antiretroviral therapy (ART) eligibility through delivering LLIN WF 10% of  in Kenya. Results Given 3-year duration intervention benefit, unit US$32 patient-year ART US$757 (2011 US$), over lifetime patients, Kenya, we estimated could yield return on investment (ROI) 11 (95% uncertainty range [UR]: 5–23), based about US$2 million costs US$26 UR: 8–50) (discounted at 3%). Our findings were subjected number sensitivity analyses. Of note, deferral potentially result 3,000 new infections not averted thus decrease US$14 million, decreasing ROI 6. Conclusions Provision be cost-saving practical method defer context highly resource-constrained environments experiencing donor fatigue for HIV/AIDS programs. Keywords : cost savings; bednets; filtration; progression; therapy; malaria; diarrhea; Kenya; sub-Saharan Africa (Published: 10 June 2015) Citation:  Glob Health Action 2015,  8 27695 -  http://dx.doi.org/10.3402/gha.v8.27695 Supplementary Material: To access supplementary material this article, please see  files  under ‘Article Tools’