Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population

摘要: Vitamin D is associated with cardiovascular disease and renal function but the mechanisms are as yet unexplained. Microalbuminuria a higher risk of kidney loss, disease, mortality. Parathyroid hormone predictor mortality negatively correlated glomerular filtration rate. We investigated association between vitamin status 5-year changes in urine albumin creatinine ratio (UACR) parathyroid (PTH). A random sample 6,784 individuals aged 30−60 years from general population participated Inter99 study 1999–2001. (serum-25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography. UACR PTH were follow-up. Increased defined >4.0 mg/g reflecting upper quartile baseline. included 4,330 who In multivariable linear regression analysis, 10-nmol/l level decrease 0.92 % (95 confidence interval, CI 0.13, 1.71). logistic odds developing increased during follow-up 0.96 0.92, 0.98) per 10 nmol/l level. found significant inverse cross-sectional (p < 0.0001) no prospective = 0.6) hormone. low to be long-term development UACR. It remains proven whether deficiency causal reversible factor albuminuria.