摘要: In the management of leukemia and malignant solid tumors [if one excepts graft-versus-leukemia (GVL) effect an allograft], bone marrow transplantation (BMT) is not therapeutic per se, but simply a method designed to overcome myelotoxicity after high-dose chemotherapy. The main limitations this are graft-versus-host disease (GVHD) in allogenic BMT contamination graft by residual cells autologous BMT. A common approach, so-called purging, has been proposed eliminate unwanted from BM before its reinjection—either normal T responsible for GVHD or cells.
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